However, these same athletes are at particular risk for kidney injury. In fact, many marathoners and other endurance athletes take NSAIDs preventively to reduce pain and possibly improve performance. NSAID use is common among people who deal with aches and pain during and after exercise. High doses and prolonged use are also risk factors. Most of the time, NSAID-related kidney problems develop in people who already have kidney disease or who take other medications that can affect kidney function. Another important item on that longer list is kidney injury. The risk of heart attack may be increased among users of NSAIDs, especially among those at increased risk (such as those who have had a previous heart attack). Upset stomach, intestinal bleeding, and cardiovascular problems are among the most important and widely recognized side effects. However, as is true for any drug, NSAIDs can cause trouble. That’s why several of them, including ibuprofen and naproxen, are available in low doses over the counter in this country and elsewhere. The safety profile of NSAIDs is generally quite good, especially when taken in small doses for short periods of time. NSAIDs are fairly safe, but not risk free Aspirin is also an NSAID, though it is usually taken in small doses for its blood thinning effects (to prevent heart attack or stroke) rather than for pain. More than a dozen different NSAIDs are available, including naproxen (as in Naprosyn or Aleve), celecoxib (Celebrex), diclofenac (Voltaren) and indomethacin (Indocin). That’s why NSAIDs are among the most commonly prescribed drugs worldwide. Millions of people have had similar experiences with ibuprofen and related medications (called non-steroidal anti-inflammatory drugs, or NSAIDs) when used for a number of conditions, including arthritis, back pain, and headache. Follow me on Twitter long ago, I took ibuprofen after a dental procedure and was amazed at how well it worked.
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